"Explorer Caused error..." & lost mouse - Help

I use Windows ME, Enternet Explorer 6 and Earthlink Total
Access 2004. Have Norton Anti-virus in use. Believe my
problems started with all the ad/spywear that's been
around. Downloaded Webroot anti-spyware. Began getting
dialog box each time computer boots saying "Explorer has
caused an error in ~8272807082.tmp. Explorer will now
close." Sometimes it would say instead "...caused an
erroe in unknown." If you click close, it shuts down
windows. I've been able to move the box to the side
almost out of sight and continue working. But now my
mouse isn't working. It boots up in Safe mode, but can't
do anything without the mouse. I did use the windows
startup disk and was able to do a scandisk from the dos
prompt. Didn't help. Don't know if there is anything
else I can do in dos to help. I'd appreciate any
suggestions. Ray