Subfolder under TIF--"Content.IE5": What is it and how aafe to delete?

I have a subfolder under WindowsTemporary Internet Files folder which is
titled: "Content.IE5".

Under this folder are several other subfolders with odd names such as
OZ4RM101, GLIFSLAJ,SVT8UAFB, etc....the files in these have a variety of
extensions such as .js .jpg .gif .htm etc....

Can I simply delete all these CONTENT.IE5 subfolders without loss of
important data and/or programs?

They arent deleted when I delete my tIF files via Inernet Explorer--Delete
files

Over the past two nights, I have gotten several Alwayup.Trojan alerts from
my Norton AntiVirus. the "infecting" files have 0 bytes and I simply selete
them manually.

But it might be a good idea to simply delete all those subfolders within
CONTENT.IE5. Are they disposable?

Thanks in advance:

-Eli