HELP! Desktop disappears when I click on it, can't click on icons

I've searched on the internet for an answer as to why I can no longer
click and open the icons on my desktop, but I haven't found an answer.
The icons don't move or anything, but the whole desktop disappears and
all you see is the wallpaper, then it goes back to normal. However, I
am able to access programs using my keyboard, but programs will
randomly close, and they give no warning.

I've scanned for trojans and viruses, and I did find one called
bluebot, but I was able to get rid of it, and it seems that that
wasn't the problem. I even did a second scan, and nothing came up.

Restarting the computer doesn't fix it, not even temporarily.