Just to add to Mike's advice ... if there are more than 4 subfolders for
CONTENT.IE5, than the malware has damaged IE's system or installation
files. Running IE's Repair Tool while in Safe Mode will rectify this.

Description of the Internet Explorer Repair Tool
http://support.microsoft.com/?id=194177

How to Start a Windows 98-Based Computer in Safe Mode
http://support.microsoft.com/?id=180902

MowGreen [MVP 2004-2005]
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*-343-* FDNY
Never Forgotten
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Mike M wrote:

Boot to Safe Mode and then clear your Temporary Internet Cache using the
GUI provided, Control Panel | Internet Options | General | Delete
Files, check the box "Delete all offline content" and then click OK and
then Apply. This should clear your cache including the various
sub-folders which are created in groups of four in the folder
Content.IE5. Clear the cache this way as this method deleted some files
that are hidden when the cache is viewed using Windows Explorer.

When you've cleared the cache check your system again for unwanted malware.